Acutissimin A

Acutissimin A (C₅₆H₃₈O₃₁) um flavono-elagitanino, um tipo de tanino formado a partir da ligação de um flavonoide com um elagitanino.

Em 2003, cientistas do Instituto Europeu de Química e Biologia, em Pessac, França descobriram que quando o tanino vescalagina presente no carvalho interage com um flavonoide no vinho, cria-se o Acutissimin A. Nos estudos separados, este composto fenólico natural tem demonstrado ser 250 vezes mais eficaz que o fármaco etopósido em deter o crescimento de tumores cancerígenos.^[1]^[2]^[3]

Referências

↑ Quideau S, Jourdes M, Saucier C, Glories Y, Pardon P, Baudry C (dezembro de 2003). «DNA topoisomerase inhibitor acutissimin a and other flavano-ellagitannins in red wine». Angewandte Chemie. 42 (48): 6012–4. PMID 14679557. doi:10.1002/anie.200352089
↑ Kashiwada Y, Nonaka G, Nishioka I, Chang JJ, Lee KH (agosto de 1992). «Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents». Journal of Natural Products. 55 (8): 1033–43. PMID 1431932. doi:10.1021/np50086a002
↑ Quideau, StéPhane; Jourdes, Michael; Saucier, Cédric; Glories, Yves; Pardon, Patrick; Baudry, Christian (2003). «DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano-Ellagitannins in Red Wine». Angewandte Chemie. 115 (48): 6194–6. doi:10.1002/ange.200352089. While it would be quite inappropriate to infer from the presence of acutissimin A in red wine that this beverage possesses antitumor properties, our work shows for the first time that wine contains polyphenolic molecules displaying both ellagitannin and flavanoid structural features.

[1] Quideau S, Jourdes M, Saucier C, Glories Y, Pardon P, Baudry C (dezembro de 2003). «DNA topoisomerase inhibitor acutissimin a and other flavano-ellagitannins in red wine». Angewandte Chemie. 42 (48): 6012–4. PMID 14679557. doi:10.1002/anie.200352089

[2] Kashiwada Y, Nonaka G, Nishioka I, Chang JJ, Lee KH (agosto de 1992). «Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents». Journal of Natural Products. 55 (8): 1033–43. PMID 1431932. doi:10.1021/np50086a002

[3] Quideau, StéPhane; Jourdes, Michael; Saucier, Cédric; Glories, Yves; Pardon, Patrick; Baudry, Christian (2003). «DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano-Ellagitannins in Red Wine». Angewandte Chemie. 115 (48): 6194–6. doi:10.1002/ange.200352089. While it would be quite inappropriate to infer from the presence of acutissimin A in red wine that this beverage possesses antitumor properties, our work shows for the first time that wine contains polyphenolic molecules displaying both ellagitannin and flavanoid structural features.

[1]

[2]

[3]