PPP2R1A
gene da espécie Homo sapiens
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform é uma enzima que em humanos é codificada pelo gene PPP2R1A.[1]
Estudos do Centro para Câncer Johns Hopkins Kimmel publicados em setembro de 2010 na revista Science demonstraram que está relacionada com o câncer de ovário. Neste caso, sua falta pode fazer a célula sadia tornar-se cancerígena.[2]
Notas e referências
- ↑ Everett AD, Xue C, Stoops T (1999). «Developmental expression of protein phosphatase 2A in the kidney». J. Am. Soc. Nephrol. 10 (8): 1737–45. PMID 10446941
- ↑ G1. «Estudo nos EUA identifica dois genes ligados ao câncer de ovário». Consultado em 9 de setembro de 2010
Leitura de apoio editar
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- Walter G, Ruediger R, Slaughter C, Mumby M (1990). «Association of protein phosphatase 2A with polyoma virus medium tumor antigen.». Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2521–5. PMC 53721
. PMID 2157202. doi:10.1073/pnas.87.7.2521 - Hemmings BA, Adams-Pearson C, Maurer F; et al. (1990). «alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.». Biochemistry. 29 (13): 3166–73. PMID 2159327. doi:10.1021/bi00465a002
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- Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). «Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.». FEBS Lett. 401 (2-3): 197–201. PMID 9013886. doi:10.1016/S0014-5793(96)01470-6
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- Ruediger R, Fields K, Walter G (1999). «Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.». J. Virol. 73 (1): 839–42. PMC 103900 . PMID 9847399
- Groves MR, Hanlon N, Turowski P; et al. (1999). «The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.». Cell. 96 (1): 99–110. PMID 9989501. doi:10.1016/S0092-8674(00)80963-0
- Hong Y, Sarge KD (1999). «Regulation of protein phosphatase 2A activity by heat shock transcription factor 2.». J. Biol. Chem. 274 (19): 12967–70. PMID 10224043. doi:10.1074/jbc.274.19.12967
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- Husi H, Ward MA, Choudhary JS; et al. (2000). «Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.». Nat. Neurosci. 3 (7): 661–9. PMID 10862698. doi:10.1038/76615
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). «Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.». EMBO J. 19 (15): 3956–67. PMC 306605 . PMID 10921877. doi:10.1093/emboj/19.15.3956
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- Elder RT, Yu M, Chen M; et al. (2001). «HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.». Virology. 287 (2): 359–70. PMID 11531413. doi:10.1006/viro.2001.1007
- Li X, Virshup DM (2002). «Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.». Eur. J. Biochem. 269 (2): 546–52. PMID 11856313. doi:10.1046/j.0014-2956.2001.02680.x
