5-alfarredutase

5-alfa redutase é uma enzima que converte a testosterona, o hormônio sexual masculino, em um outro mais potente, a di-hidrotestosterona.^[1]

Testosterona
Di-hidrotestosterona

A 5-alfa redutase é produzida em diversos órgãos dos humanos de ambos os sexos.^[2]^[3]^[4]^[5]

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Inibidor da 5-alfarredutase

Referências

↑ M. Streiber. "Hybridinhibitoren der humanen 5α-Reduktase: Ein neues Konzept zur Hemmung der 5α-Reduktase Isoenzyme Typ I und Typ II. Dissertation" . Universität Saarbrücken.
↑ Pinna G, Agis-Balboa RC, Pibiri F, Nelson M, Guidotti A, Costa E (outubro de 2008). «Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice». Neurochemical Research. 33 (10): 1990–2007. PMID 18473173. doi:10.1007/s11064-008-9718-5
↑ Yamana K, Labrie F, Luu-The V (agosto de 2010). «Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride». Hormone Molecular Biology and Clinical Investigation. 2 (3): 293–9. PMID 25961201. doi:10.1515/hmbci.2010.035
↑ Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (setembro de 2006). «Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis». Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14602–7. Bibcode:2006PNAS..10314602A. PMC 1600006 . PMID 16984997. doi:10.1073/pnas.0606544103
↑ Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A (novembro de 2007). «Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice». Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18736–41. Bibcode:2007PNAS..10418736A. PMC 2141846 . PMID 18003893. doi:10.1073/pnas.0709419104

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[1] M. Streiber. "Hybridinhibitoren der humanen 5α-Reduktase: Ein neues Konzept zur Hemmung der 5α-Reduktase Isoenzyme Typ I und Typ II. Dissertation" . Universität Saarbrücken.

[pmid18473173-2] Pinna G, Agis-Balboa RC, Pibiri F, Nelson M, Guidotti A, Costa E (outubro de 2008). «Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice». Neurochemical Research. 33 (10): 1990–2007. PMID 18473173. doi:10.1007/s11064-008-9718-5

[Yamana_2010-3] Yamana K, Labrie F, Luu-The V (agosto de 2010). «Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride». Hormone Molecular Biology and Clinical Investigation. 2 (3): 293–9. PMID 25961201. doi:10.1515/hmbci.2010.035

[pmid16984997-4] Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (setembro de 2006). «Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis». Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14602–7. Bibcode:2006PNAS..10314602A. PMC 1600006 . PMID 16984997. doi:10.1073/pnas.0606544103

[pmid18003893-5] Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A (novembro de 2007). «Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice». Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18736–41. Bibcode:2007PNAS..10418736A. PMC 2141846 . PMID 18003893. doi:10.1073/pnas.0709419104

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