Poxviridae: diferenças entre revisões

Replication of the poxvirus involves several stages. The first thing the [[virus]] does is to bind to a receptor on the host cell surface; the receptors for the poxvirus are currently unknown. After binding to the receptor, the [[virus]] enters the cell where it uncoats. Uncoating of the [[virus]] is a two step process. Firstly the outer membrane is removed as the particle enters the cell; secondly the [[virus]] particle (without the outer membrane) is uncoated further to release the core into the [[cytoplasm]]. The pox viral [[genes]] are expressed in two phases. The early [[genes]] are expressed first. These [[genes]] the non-structural [[protein]], including [[proteins]] necessary for replication of the viral [[genome]], and are expressed before the [[genome]] is replicated. The late [[genes]] are expressed after the [[genome]] has been replicated and encode the structural [[proteins]] to make the [[virus]] particle. The assembly of the [[virus]] particle occurs in the [[cytoskeleton]] of the cell and is a complex process that is poorly understood but is currently being researched. Considering the fact that this [[virus]] is large and complex replication is relatively quick taking only 12 hours approximately. The replication of this virus is unusual for a [[virus]] with double stranded [[DNA]] [[genome]] because it encodes its own machinery for [[genome]] replication and therefore the replication occurs in the [[cytoplasm]]. Most [[viruses]] with a double stranded [[DNA]] [[genome]] replicate in the [[cell nucleus|nucleus]] and use the host cells [[genome]] replication machinery.