HIST1H1A

H1-1
Identificadores
Nomes alternativos	H1-1, HIST1H1A
IDs externos	OMIM: 142709 HomoloGene: 134658 GeneCards: H1-1
Ontologia genética
Função molecular	• DNA binding; • chromatin DNA binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • heparin binding; • double-stranded DNA binding; • nucleosomal DNA binding;
Componente celular	• nucleossoma; • núcleo celular; • cromossoma; • cell surface; • vesícula;
Processo biológico	• nucleosome assembly; • espermatogênese; • positive regulation of receptor-mediated endocytosis; • GO:0009373 regulation of transcription, DNA-templated; • chromosome condensation; • negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	3024
	n/a
	ENSG00000124610
	n/a
	Q02539
	n/a
	NM_005325
	n/a
	NP_005316
	n/a
	Wikidata
Ver/Editar Humano

A Histona H1.1 é uma proteína que em humanos é codificada pelo gene HIST1H1A.^[2]^[3]^[4]

A histona ligante, H1, interage com o DNA ligante entre nucleossomos e funciona na compactação da cromatina em estruturas de ordem superior. Este gene é sem intrones e codifica um membro da família histona H1. Os transcritos desse gene não possuem caudas de poli A, mas contêm um elemento de terminação palindrômico. Esse gene é encontrado no grande agrupamento de genes de histonas no cromossomo 6.^[4]

Leitura adicional editar

Du Clos TW, Zlock LT, Marnell L (1991). «Definition of a C-reactive protein binding determinant on histones.». J. Biol. Chem. 266 (4): 2167–71. PMID 1989977
Gurley LR, Valdez JG, Buchanan JS (1996). «Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase.». J. Biol. Chem. 270 (46): 27653–60. PMID 7499230. doi:10.1074/jbc.270.46.27653
Burfeind P, Hoyer-Fender S, Doenecke D, et al. (1995). «Expression and chromosomal mapping of the gene encoding the human histone H1.1.». Hum. Genet. 94 (6): 633–9. PMID 7989039. doi:10.1007/bf00206957
Albig W, Drabent B, Kunz J, et al. (1993). «All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6.». Genomics. 16 (3): 649–54. PMID 8325638. doi:10.1006/geno.1993.1243
O'Connor PM, Ferris DK, Pagano M, et al. (1993). «G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.». J. Biol. Chem. 268 (11): 8298–308. PMID 8463339
Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). «Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay.». Biochim. Biophys. Acta. 1296 (2): 219–27. PMID 8814229. doi:10.1016/0167-4838(96)00072-6
Albig W, Kioschis P, Poustka A, et al. (1997). «Human histone gene organization: nonregular arrangement within a large cluster.». Genomics. 40 (2): 314–22. PMID 9119399. doi:10.1006/geno.1996.4592
Meergans T, Albig W, Doenecke D (1998). «Conserved sequence elements in human main type-H1 histone gene promoters: their role in H1 gene expression.». Eur. J. Biochem. 256 (2): 436–46. PMID 9760185. doi:10.1046/j.1432-1327.1998.2560436.x
Carrier F, Georgel PT, Pourquier P, et al. (1999). «Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin». Mol. Cell. Biol. 19 (3): 1673–85. PMC 83961 . PMID 10022855
Silljé HH, Takahashi K, Tanaka K, et al. (1999). «Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication». EMBO J. 18 (20): 5691–702. PMC 1171636 . PMID 10523312. doi:10.1093/emboj/18.20.5691
Richardson RT, Batova IN, Widgren EE, et al. (2000). «Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein». J. Biol. Chem. 275 (39): 30378–86. PMID 10893414. doi:10.1074/jbc.M003781200
Lever MA, Th'ng JP, Sun X, Hendzel MJ (2001). «Rapid exchange of histone H1.1 on chromatin in living human cells». Nature. 408 (6814): 873–6. PMID 11130728. doi:10.1038/35048603
Chadwick BP, Willard HF (2001). «A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome». J. Cell Biol. 152 (2): 375–84. PMC 2199617 . PMID 11266453. doi:10.1083/jcb.152.2.375
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899
Coleman MA, Miller KA, Beernink PT, et al. (2004). «Identification of chromatin-related protein interactions using protein microarrays». Proteomics. 3 (11): 2101–7. PMID 14595808. doi:10.1002/pmic.200300593
Hendzel MJ, Lever MA, Crawford E, Th'ng JP (2004). «The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo». J. Biol. Chem. 279 (19): 20028–34. PMID 14985337. doi:10.1074/jbc.M400070200
Cohen-Armon M, Visochek L, Katzoff A, et al. (2004). «Long-term memory requires polyADP-ribosylation». Science. 304 (5678): 1820–2. PMID 15205535. doi:10.1126/science.1096775
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504

Referências

↑ «Human PubMed Reference:»
↑ Eick S, Nicolai M, Mumberg D, Doenecke D (setembro de 1989). «Human H1 histones: conserved and varied sequence elements in two H1 subtype genes». Eur J Cell Biol. 49 (1): 110–5. PMID 2759094
↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (outubro de 2002). «The human and mouse replication-dependent histone genes». Genomics. 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3
↑ ^a ^b «Entrez Gene: HIST1H1A histone cluster 1, H1a»

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[1] «Human PubMed Reference:»

[pmid2759094-2] Eick S, Nicolai M, Mumberg D, Doenecke D (setembro de 1989). «Human H1 histones: conserved and varied sequence elements in two H1 subtype genes». Eur J Cell Biol. 49 (1): 110–5. PMID 2759094

[pmid12408966-3] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (outubro de 2002). «The human and mouse replication-dependent histone genes». Genomics. 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3

[entrez-4] «Entrez Gene: HIST1H1A histone cluster 1, H1a»

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