Prêmio Wolf de Medicina

O Prêmio Wolf de Medicina é concedido quase anualmente[1] pela Fundação Wolf em Israel. É um dos seis Prêmios Wolf estabelecidos pela fundação e concedido desde 1978; os outros são em Agronomia, Artes, Física, Matemática e Química. É provavelmente o terceiro mais significativo prêmio de medicina, após o Nobel de Fisiologia ou Medicina e o Prêmio Lasker.


Ano Nome Nacionalidade Citação
1978 George Davis Snell   Estados Unidos for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response.
Jean Dausset   França for discovering the HL-A system, the major histocompatibility complex in man and its primordial role in organ transplantation.
Jon van Rood   Países Baixos for his contribution to the understanding of the complexity of the HL-A system in man and its implications in transplantation and in disease.
1979 Roger Sperry   Estados Unidos for his studies on the functional differentiation of the right and left hemispheres of the brain.
Arvid Carlsson   Suécia for his work which established the role of dopamine as a neurotransmitter.
Oleh Hornykiewicz   Áustria for opening a new approach in the control of Parkinson's disease by L-Dopa.
1980 César Milstein
Leo Sachs
James Learmonth Gowans
  Argentina /   Reino Unido;
  Reino Unido
for their contributions to knowledge of the function and dysfunction of the body cells through their studies on the immunological role of the lymphocytes, the development of specific antibodies and the elucidation of mechanisms governing the control and differentiation of normal and cancer cells.
1981 Barbara McClintock   Estados Unidos for her imaginative and important contributions to our understanding of chromosome structure behaviour and function, and for her identification and description of transposable genetic (mobile) elements.
Stanley Norman Cohen for his concepts underlying genetic engineering; for constructing a biologically functional hybrid plasmid, and for achieving actual expression of a foreign gene implanted in E. coli by the recombinant DNA method.
1982 Jean-Pierre Changeux   França for the isolation, purification and characterization of the acetylcholine receptor.
Solomon Halbert Snyder   Estados Unidos for the development of the ways to label neurotransmitter receptors which provide tools to describe their properties.
James Black   Reino Unido for developing agents which block beta adrenergic and histamine receptors.
1983/4 No award
1984/5 Donald Frederick Steiner   Estados Unidos for his discoveries concerning the bio-synthesis and processing of insulin which have had profound implications for basic biology and clinical medicine.
1986 Osamu Hayaishi   Japão for his discovery of the oxygenase enzymes and elucidation of their structure and biological importance.
1987 Pedro Cuatrecasas
Meir Wilchek
  Estados Unidos
for the invention and development of affinity chromatography and its applications to biomedical sciences.
1988 Henri-Géry Hers
Elizabeth Neufeld
  Estados Unidos
for the biochemical elucidation of lysosomal storage diseases and the resulting contributions to biology, pathology, prenatal diagnosis and therapeutics.
1989 John Gurdon   Reino Unido for his introduction of the xenopus oocyte into molecular biology and his demonstration that the nucleus of a differentiated cell and of the egg differ in expression but not in the content of genetic material.
Edward Lewis   Estados Unidos for his demonstration and exploration of the genetic control of the development of body segments by homeotic genes.
1990 Maclyn McCarty for his part in the demonstration that the transforming factor in bacteria is due to deoxyribonucleic acid (DNA) and the concomitant discovery that the genetic material is composed of DNA.
1991 Seymour Benzer for having generated a new field of molecular neurogenetics by his pioneering research on the dissection of the nervous system and behavior by gene mutations.
1992 Judah Folkman for his discoveries which originated the concept and developed the field of angiogenesis research.
1993 No award
1994/5 Michael Berridge
Yasutomi Nishizuka
  Reino Unido
for their discoveries concerning cellular transmembrane signalling involving phospholipids and calcium.
1995/6 Stanley Prusiner   Estados Unidos for discovering prions, a new class of pathogens that cause important neurodegenerative disease by inducing changes in protein structure.
1997 Mary Frances Lyon   Reino Unido for her hypothesis concerning the random inactivation of X-chromosomes in mammals.
1998 Michael Sela
Ruth Arnon
for their major discoveries in the field of immunology.
1999 Eric Kandel   Estados Unidos for the elucidation of the organismic, cellular and molecular mechanisms whereby short-term memory is converted to a long-term form.
2000 No award
2001 Avram Hershko
Alexander Varshavsky
  Rússia /   Estados Unidos
for the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation.
2002/3 Ralph Lawrence Brinster   Estados Unidos for the development of procedures to manipulate mouse ova and embryos, which has enabled transgenesis and its applications in mice.
Mario Capecchi
Oliver Smithies
  Itália /   Estados Unidos;
  Reino Unido /   Estados Unidos
for their contribution to the development of gene-targeting, enabling elucidation of gene function in mice.
2004 Robert Allan Weinberg   Estados Unidos for his discovery that cancer cells including human tumor cells, carry somatically mutated genes-oncogenes that operate to drive their malignant proliferation.
Roger Tsien for his seminal contribution to the design and biological application of novel fluorescent and photolabile molecules to analyze and perturb cell signal transduction.
2005 Alexander Levitzki   Israel for pioneering signal transduction therapy and for developing tyrosine kinase inhibitors as effective agents against cancer and a range of other diseases.
Anthony Rex Hunter   Reino Unido /   Estados Unidos for the discovery of protein kinases that phosphorylate tyrosine residues in proteins, critical for the regulation of a wide variety of cellular events, including malignant transformation.
Anthony Pawson   Reino Unido /   Canadá for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer.
2006/7 No award
2008 Howard Cedar
Aharon Razin
for their fundamental contributions to our understanding of the role of DNA methylation in the control of gene expression.
2009 No award
2010 Axel Ullrich   Alemanha for groundbreaking cancer research that has led to development of new drugs.
2011 Shinya Yamanaka
Rudolf Jaenisch
  Estados Unidos /   Alemanha
for the generation of induced pluripotent stem cells (iPS cells) from skin cells (SY) and demonstration that iPS cells can be used to cure genetic disease in a mammal, thus establishing their therapeutic potential (RJ).
2012 Ronald Mark Evans   Estados Unidos for his discovery of the gene super-family encoding nuclear receptors and elucidating the mechanism of action of this class of receptors.[3]
2013 No award
2014 Nahum Sonenberg   Israel /   Canadá for his discovery of the proteins that control the protein expression mechanism and their operation.
Gary Ruvkun
Victor Ambros
  Estados Unidos for the discovery of the micro-RNA molecules that play a key role in controlling gene expression in natural processes and disease development.
2015 John Kappler
Philippa Marrack
for major contributions to the understanding of the key antigen-specific molecules, the T cell receptor for antigen and antibodies and how these molecules participate in immune recognition and effector function.
Jeffrey Ravetch
2016 Carl Ronald Kahn   Estados Unidos for pioneering studies defining insulin signaling and its alterations in disease.
Lewis Cantley   Estados Unidos for discovery of phosphoinositide- 3 kinases and their roles in physiology and disease.
2017 James Patrick Allison   Estados Unidos for a revolution in cancer treatment due to the discovery of the immune control barrier.
2018 Não houve premiação
2019 Jeffrey Michael Friedman   Estados Unidos for the discovery of Leptin and the entirely new endocrine system controlling body weight (and many other processes).[4]
2020 Emmanuelle Charpentier   França for deciphering and repurposing the bacterial CRISPR/Cas9 immune system for genome editing.
Jennifer Doudna   Estados Unidos for revealing the medicine-revolutionizing mechanism of bacterial immunity via RNA-guided genome editing.[5]


  1. The Wolf Foundation website describes the prize as annual; however, some prizes are split across years, while in some years no prize is awarded.
  2. Simply-Smart. «תוצאות חיפוש - פרס וולף» 
  3. «nctimes - Wolf Prize 2012 in Medicine». Consultado em 5 de janeiro de 2013. Arquivado do original em 22 de fevereiro de 2012 
  4. Wolf Prize 2019 - Medicine
  5. Wolf Prize 2020 - Medicine

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