Epiandrosterona

A epiandrosterona ou isoandrosterona,^[1]^[2] também chamada 3β-androsterona, 3β-hidroxi-5α-androstan-17-ona ou 5α-androstan-3β-ol-17-ona,^[3] é uma hormona esteróide com uma débil actividade androgénica. É um metabólito da testosterona e di-hidrotestosterona (DHT).

A epiandrosterona aparece de forma natural na maioria dos mamíferos, entre eles os porcos.^[4]

A epiandrosterona produz a enzima 5α-redutase a partir da hormona adrenal desidroepiandrosterona (DHEA).^[5]^[6]^[7]^[8]^[9]

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Referências

↑ Samuel H. Yalkowsky; Yan He; Parijat Jain (19 de abril de 2016). Handbook of Aqueous Solubility Data, Second Edition. [S.l.]: CRC Press. pp. 1209–. ISBN 978-1-4398-0246-5
↑ Natural Products. [S.l.]: Krishna Prakashan Media. 2006. pp. 298–. ISBN 978-81-87224-85-3
↑ ChemSpider Epiandrosterone
↑ Raeside JI, Renaud RL, Marshall DE. Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine Leydig cells and their presence in testicular venous blood. J Steroid Biochem Mol Biol. 42(1):113-20, 1992. PMID 1558816
↑ PubChem Epiandrosterone
↑ Callies F, Arlt W, Siekmann L, Hübler D, Bidlingmaier F, Allolio B. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids. 65(2):98-102, 2000. PMID 10639021
↑ Labrie F, Cusan L, Gomez JL, Martel C, Bérubé R, Bélanger P, Chaussade V, Deloche C, Leclaire J. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol. 2008 May;110(1-2):1-9. PMID 18359622. DOI 10.1016/j.jsbmb.2008.02.003
↑ Daniël Henri van de Kerkhof. Steroid profiling in doping analysis. [S.l.] : [s.n.], 2001 - Tekst. - Proefschrift Universiteit Utrecht [1]
↑ Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril. Mar;81(3):595-604, 2004. PMID 15037408. DOI 10.1016/j.fertnstert.2003.07.035

Bibliografia editar

Simons RG, Grinwich DL. Immunoreactive detection of four mammalian steroids in plants. Can J Bot 67: 288-296, 1989
Janeczko A, Skoczowski A. Mammalian sex hormones in plants. Folia Histochem Cytobiol. 2005;43(2):71-9.Labrie F, Bélanger A, Labrie C, Candas B, Cusan L, Gomez 4. JL. Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women. J Steroid Biochem Mol Biol. 107(1-2):57-69, 2007
Uralets VP, Gillette PA. Over-the-counter delta5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3beta, 17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men. J Anal Toxicol. 24(3):188-93, 2000

[YalkowskyHe2016-1] Samuel H. Yalkowsky; Yan He; Parijat Jain (19 de abril de 2016). Handbook of Aqueous Solubility Data, Second Edition. [S.l.]: CRC Press. pp. 1209–. ISBN 978-1-4398-0246-5

[KrishnaPrakashanMedia2006-2] Natural Products. [S.l.]: Krishna Prakashan Media. 2006. pp. 298–. ISBN 978-81-87224-85-3

[3] ChemSpider Epiandrosterone

[4] Raeside JI, Renaud RL, Marshall DE. Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine Leydig cells and their presence in testicular venous blood. J Steroid Biochem Mol Biol. 42(1):113-20, 1992. PMID 1558816

[5] PubChem Epiandrosterone

[6] Callies F, Arlt W, Siekmann L, Hübler D, Bidlingmaier F, Allolio B. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids. 65(2):98-102, 2000. PMID 10639021

[7] Labrie F, Cusan L, Gomez JL, Martel C, Bérubé R, Bélanger P, Chaussade V, Deloche C, Leclaire J. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol. 2008 May;110(1-2):1-9. PMID 18359622. DOI 10.1016/j.jsbmb.2008.02.003

[8] Daniël Henri van de Kerkhof. Steroid profiling in doping analysis. [S.l.] : [s.n.], 2001 - Tekst. - Proefschrift Universiteit Utrecht [1]

[9] Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril. Mar;81(3):595-604, 2004. PMID 15037408. DOI 10.1016/j.fertnstert.2003.07.035

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