Predefinição:PBB/207

V-akt murine thymoma viral oncogene homolog 1
PDB rendering based on 1h10.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1
Identificadores
Símbolos	AKT1; AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
IDs externos	OMIM: 164730 MGI: 87986 HomoloGene: 3785 ChEMBL: 4282 GeneCards: AKT1 Gene
Número EC	2.7.11.1
Ontologia do gene Função molecular •protein kinase activity •protein serine/threonine kinase activity •protein serine/threonine/tyrosine kinase activity •protein kinase C binding •protein binding •ATP binding •phosphatidylinositol-3,4,5-trisphosphate binding •kinase activity •enzyme binding •nitric-oxide synthase regulator activity •identical protein binding •phosphatidylinositol-3,4-bisphosphate binding •14-3-3 protein binding Componente celular •nucleus •nucleoplasm •cytoplasm •spindle •cytosol •plasma membrane •microtubule cytoskeleton Processo biológico •protein import into nucleus, translocation •osteoblast differentiation •maternal placenta development •positive regulation of protein phosphorylation •positive regulation of endothelial cell proliferation •glycogen biosynthetic process •regulation of glycogen biosynthetic process •glucose metabolic process •translation •regulation of translation •cellular protein modification process •protein phosphorylation •negative regulation of protein kinase activity •nitric oxide biosynthetic process •apoptotic process •activation-induced cell death of T cells •inflammatory response •signal transduction •epidermal growth factor receptor signaling pathway •G-protein coupled receptor signaling pathway •germ cell development •aging •blood coagulation •cell proliferation •insulin receptor signaling pathway •fibroblast growth factor receptor signaling pathway •apoptotic mitochondrial changes •response to heat •gene expression •negative regulation of autophagy •negative regulation of plasma membrane long-chain fatty acid transport •positive regulation of sodium ion transport •positive regulation of glucose metabolic process •negative regulation of endopeptidase activity •regulation of neuron projection development •glucose transport •RNA metabolic process •mRNA metabolic process •phosphorylation •protein ubiquitination •peptidyl-serine phosphorylation •cell projection organization •cell differentiation •protein catabolic process •platelet activation •hyaluronan metabolic process •positive regulation of cell growth •regulation of cell migration •endocrine pancreas development •T cell costimulation •positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle •negative regulation of fatty acid beta-oxidation •response to food •positive regulation of cellular protein metabolic process •peripheral nervous system myelin maintenance •positive regulation of proteasomal ubiquitin-dependent protein catabolic process •cellular response to insulin stimulus •positive regulation of peptidyl-serine phosphorylation •response to fluid shear stress •intracellular signal transduction •Fc-epsilon receptor signaling pathway •glucose homeostasis •anagen •positive regulation of apoptotic process •negative regulation of apoptotic process •negative regulation of cysteine-type endopeptidase activity involved in apoptotic process •protein kinase B signaling •positive regulation of blood vessel endothelial cell migration •small molecule metabolic process •innate immune response •positive regulation of nitric oxide biosynthetic process •positive regulation of fat cell differentiation •positive regulation of glycogen biosynthetic process •negative regulation of cell size •negative regulation of proteolysis •positive regulation of vasoconstriction •positive regulation of transcription from RNA polymerase II promoter •nitric oxide metabolic process •positive regulation of glucose import •negative regulation of JNK cascade •protein autophosphorylation •positive regulation of lipid biosynthetic process •insulin-like growth factor receptor signaling pathway •neurotrophin TRK receptor signaling pathway •phosphatidylinositol-mediated signaling •regulation of nitric-oxide synthase activity •positive regulation of nitric-oxide synthase activity •positive regulation of sequence-specific DNA binding transcription factor activity •striated muscle cell differentiation •mammary gland epithelial cell differentiation •glycogen cell differentiation involved in embryonic placenta development •labyrinthine layer blood vessel development •membrane organization •response to UV-A •cellular response to mechanical stimulus •cellular response to epidermal growth factor stimulus •cellular response to hypoxia •positive regulation of establishment of protein localization to plasma membrane •negative regulation of release of cytochrome c from mitochondria •intrinsic apoptotic signaling pathway •execution phase of apoptosis •positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway •regulation of cell cycle checkpoint •negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway •negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	207	11651
Ensembl	ENSG00000142208	ENSMUSG00000001729
UniProt	P31749	P31750
RefSeq (mRNA)	NM_001014431	NM_001165894
RefSeq (proteína)	NP_001014431	NP_001159366
Localização (UCSC)	Chr 14: 105.24 – 105.26 Mb	Chr 12: 112.65 – 112.67 Mb
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