Predefinição:PBB/3458

Interferon-gama
Renderização baseada em PDB 1d9c
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1EKU, 1FG9, 1FYH, 1HIG, 3BES
Identificadores
Símbolos	IFNG; IFG; IFI
IDs externos	OMIM: 147570 MGI: 107656 HomoloGene: 55526 GeneCards: IFNG Gene
Ontologia do gene Função molecular •cytokine activity •interferon-gamma receptor binding Componente celular •região extracelular •extracellular space •external side of plasma membrane Processo biológico •protein import into nucleus, translocation •negative regulation of transcription from RNA polymerase II promoter •neutrophil apoptotic process •regulation of the force of heart contraction •positive regulation of mesenchymal cell proliferation •adaptive immune response •CD8-positive, alpha-beta T cell differentiation involved in immune response •negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis •apoptotic process •cellular component movement •humoral immune response •ciclo celular arrest •superfície celular receptor signaling pathway •response to virus •cytokine-mediated signaling pathway •antigen processing and presentation •neutrophil chemotaxis •endoplasmic reticulum unfolded protein response •negative regulation of myelination •positive regulation of synaptic transmission, cholinergic •negative regulation of interleukin-17 production •positive regulation of interleukin-12 production •positive regulation of interleukin-23 production •positive regulation of tumor necrosis factor production •positive regulation of peptidyl-serine phosphorylation of STAT protein •positive regulation of smooth muscle cell apoptotic process •positive regulation of T cell proliferation •response to drug •positive regulation of tyrosine phosphorylation of Stat1 protein •defense response to bacterium •defense response to protozoan •negative regulation of growth of symbiont in host •positive regulation of chemokine biosynthetic process •positive regulation of interleukin-12 biosynthetic process •positive regulation of MHC class II biosynthetic process •positive regulation of interleukin-6 biosynthetic process •positive regulation of nitric oxide biosynthetic process •positive regulation of neuron differentiation •positive regulation of osteoclast differentiation •positive regulation of cell adhesion •positive regulation of transcription from RNA polymerase II promoter •positive regulation of isotype switching to IgG isotypes •negative regulation of smooth muscle cell proliferation •positive regulation of interleukin-1 beta secretion •regulation of insulin secretion •positive regulation of membrane protein ectodomain proteolysis •defense response to virus •positive regulation of killing of cells of other organism •interferon-gamma-mediated signaling pathway •regulation of interferon-gamma-mediated signaling pathway •positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity •positive regulation of fructose 1,6-bisphosphate metabolic process •positive regulation of vitamin D biosynthetic process •positive regulation of calcidiol 1-monooxygenase activity •cellular response to lipopolysaccharide •cellular response to interleukin-18 •negative regulation of metanephric nephron tubule epithelial cell differentiation •positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	3458	15978
Ensembl	ENSG00000111537	ENSMUSG00000055170
UniProt	P01579	P01580
RefSeq (mRNA)	NM_000619.2	NM_008337.3
RefSeq (proteína)	NP_000610.2	NP_032363.1
Localização (UCSC)	Chr 12: 68.55 – 68.55 Mb	Chr 10: 118.44 – 118.45 Mb
Busca PubMed	[1]	[2]