Predefinição:PBB/3643

Receptor de insulina
(PDB:3LOH)
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2DTG, 2HR7, 2Z8C, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3LOH
Identificadores
Símbolos	INSR; CD220; HHF5
IDs externos	OMIM: 147670 MGI: 96575 HomoloGene: 20090 ChEMBL: 1981 GeneCards: INSR Gene
Número EC	2.7.10.1
Ontologia do gene Função molecular •protein tyrosine kinase activity •receptor signaling protein tyrosine kinase activity •insulin-activated receptor activity •insulin-like growth factor receptor binding •protein binding •ATP binding •GTP binding •protein phosphatase binding •lipoic acid binding •insulin-like growth factor I binding •insulin-like growth factor II binding •protein complex binding •SH2 domain binding •3-phosphoinositide-dependent protein kinase binding •phosphatidylinositol 3-kinase binding •insulin binding •insulin receptor substrate binding •PTB domain binding Componente celular •nucleus •cytosol •plasma membrane •integral to plasma membrane •insulin receptor complex •caveola •endosome membrane •membrane •synapse Processo biológico •activation of MAPK activity •negative regulation of protein phosphorylation •positive regulation of protein phosphorylation •heart morphogenesis •carbohydrate metabolic process •regulation of transcription, DNA-dependent •G-protein coupled receptor signaling pathway •positive regulation of cell proliferation •insulin receptor signaling pathway •response to glucose stimulus •response to manganese ion •regulation of hydrogen peroxide metabolic process •positive regulation of glycoprotein biosynthetic process •negative regulation of gene expression •response to activity •peptidyl-tyrosine phosphorylation •transformation of host cell by virus •signal transduction by phosphorylation •male sex determination •positive regulation of cell migration •exocrine pancreas development •activation of protein kinase activity •activation of protein kinase B activity •response to estradiol stimulus •negative regulation of transporter activity •cellular response to insulin stimulus •response to vitamin D •response to testosterone stimulus •response to tumor necrosis factor •glucose homeostasis •positive regulation of MAPK cascade •positive regulation of nitric oxide biosynthetic process •fat cell differentiation •response to ethanol •positive regulation of glycogen biosynthetic process •positive regulation of DNA replication •positive regulation of glycolysis •positive regulation of mitosis •regulation of embryonic development •positive regulation of glucose import •protein autophosphorylation •positive regulation of developmental growth •protein heterotetramerization •response to glucocorticoid stimulus •positive regulation of protein kinase B signaling cascade •positive regulation of respiratory burst •cellular response to growth factor stimulus Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	3643	16337
Ensembl	ENSG00000171105	ENSMUSG00000005534
UniProt	P06213	P15208
RefSeq (mRNA)	NM_000208.2	NM_010568.2
RefSeq (proteína)	NP_000199.2	NP_034698.2
Localização (UCSC)	Chr 19: 7.11 – 7.29 Mb	Chr 8: 3.15 – 3.28 Mb
Busca PubMed	[1]	[2]