Predefinição:PBB/672

Breast cancer 1, early onset
Renderização PDB baseada em 1jm7.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3K16, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK
Identificadores
Símbolos	BRCA1; BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53
IDs externos	OMIM: 113705 MGI: 104537 HomoloGene: 5276 ChEMBL: 5990 GeneCards: BRCA1 Gene
Ontologia do gene Função molecular •DNA binding •transcription coactivator activity •RNA binding •ubiquitin-protein transferase activity •protein binding •zinc ion binding •tubulin binding •ligase activity •enzyme binding •ubiquitin protein ligase binding •transcription regulatory region DNA binding •androgen receptor binding Componente celular •ubiquitin ligase complex •ruffle •nucleus •nucleoplasm •chromosome •cytoplasm •plasma membrane •focal adhesion •gamma-tubulin ring complex •ribonucleoprotein complex •BRCA1-BARD1 complex •filamentous actin •protein complex •BRCA1-A complex Processo biológico •double-strand break repair via homologous recombination •DNA repair •postreplication repair •double-strand break repair •regulation of transcription from RNA polymerase II promoter •regulation of transcription from RNA polymerase III promoter •fatty acid biosynthetic process •apoptotic process •cellular response to DNA damage stimulus •DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator •chromosome segregation •intrinsic apoptotic signaling pathway in response to DNA damage •response to ionizing radiation •protein ubiquitination •androgen receptor signaling pathway •positive regulation of protein ubiquitination •G2 DNA damage checkpoint •substrate adhesion-dependent cell spreading •positive regulation of histone acetylation •regulation of cell proliferation •regulation of apoptotic process •response to estrogen •negative regulation of fatty acid biosynthetic process •positive regulation of DNA repair •negative regulation of transcription, DNA-templated •positive regulation of transcription, DNA-templated •positive regulation of transcription from RNA polymerase II promoter •negative regulation of centriole replication •positive regulation of histone H3-K4 methylation •negative regulation of histone H3-K9 methylation •protein autoubiquitination •positive regulation of histone H4-K20 methylation •positive regulation of cell cycle arrest •cellular response to indole-3-methanol •protein K6-linked ubiquitination •regulation of cell motility •positive regulation of histone H3-K9 acetylation •positive regulation of histone H4-K16 acetylation Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	672	12189
Ensembl	ENSG00000012048	ENSMUSG00000017146
UniProt	P38398	P48754
RefSeq (mRNA)	NM_007294	NM_009764
RefSeq (proteína)	NP_009225	NP_033894
Localização (UCSC)	Chr 17: 41.2 – 41.28 Mb	Chr 11: 101.49 – 101.55 Mb
Busca PubMed	[1]	[2]