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Predefinição
:
PBB/7498
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Predefinição:PBB
Xantina desidrogenase
Renderização com base em
PDB
1fiq.
Estruturas disponíveis
PDB
Busca de ortólogos:
PDBe
,
RCSB
Lista de códigos PDB
2CKJ
,
2E1Q
Identificadores
Símbolos
XDH
; XO; XOR
IDs externos
OMIM:
607633
MGI
:
98973
HomoloGene
:
324
ChEMBL
:
1929
GeneCards
:
XDH Gene
Número EC
1.17.3.2 1.17.1.4, 1.17.3.2
Ontologia do gene
Função molecular
•
xanthine dehydrogenase activity
•
xanthine oxidase activity
•
iron ion binding
•
UDP-N-acetylmuramate dehydrogenase activity
•
electron carrier activity
•
protein homodimerization activity
•
molybdopterin cofactor binding
•
flavin adenine dinucleotide binding
•
2 iron, 2 sulfur cluster binding
Componente celular
•
extracellular space
•
peroxisome
•
cytosol
Processo biológico
•
negative regulation of protein phosphorylation
•
negative regulation of endothelial cell proliferation
•
purine nucleobase metabolic process
•
purine nucleotide catabolic process
•
activation of cysteine-type endopeptidase activity involved in apoptotic process
•
lactation
•
xanthine catabolic process
•
negative regulation of gene expression
•
small molecule metabolic process
•
negative regulation of endothelial cell differentiation
•
negative regulation of protein kinase B signaling
•
nucleobase-containing small molecule metabolic process
•
oxidation-reduction process
•
positive regulation of p38MAPK cascade
•
negative regulation of vascular endothelial growth factor signaling pathway
•
positive regulation of reactive oxygen species metabolic process
•
negative regulation of vasculogenesis
Sources:
Amigo
/
QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies
Humano
Rato
Entrez
7498
22436
Ensembl
ENSG00000158125
ENSMUSG00000024066
UniProt
P47989
Q00519
RefSeq (mRNA)
NM_000379
NM_011723
RefSeq (proteína)
NP_000370
NP_035853
Localização (UCSC)
Chr 2:
31.56 – 31.64 Mb
Chr 17:
73.88 – 73.95 Mb
Busca
PubMed
[1]
[2]
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