AARS2

AARS2
Identificadores
Nomes alternativos	AARS2
IDs externos	OMIM: 612035 HomoloGene: 56897 GeneCards: AARS2
Doenças Geneticamente Relacionadas
	ovarioleukodystrophy
Ontologia genética
Função molecular	• aminoacyl-tRNA ligase activity; • nucleotide binding; • amino acid binding; • tRNA binding; • metal ion binding; • ligase activity; • RNA binding; • nucleic acid binding; • alanine-tRNA ligase activity; • ATP binding; • zinc ion binding; • aminoacyl-tRNA editing activity;
Componente celular	• citoplasma; • mitocôndria;
Processo biológico	• tRNA aminoacylation; • síntese proteica; • alanyl-tRNA aminoacylation; • tRNA modification; • mitochondrial alanyl-tRNA aminoacylation; • mitochondrial respiratory chain complex assembly; • aminoacyl-tRNA metabolism involved in translational fidelity;
	Sources:Amigo / QuickGO
Ortólogos
	57505
	n/a
	ENSG00000124608
	n/a
	Q5JTZ9
	n/a
	NM_020745
	n/a
	NP_065796
	n/a
	Wikidata
Ver/Editar Humano

A enzima Alanina-tRNA sintetase mitocondrial, também conhecida como alanina-tRNA ligase (AlaRS) ou alanina-tRNA sintetase 2 (AARS2), é uma enzima que em humanos é codificada pelo gene AARS2.^[3]^[4]

Referências

↑ «Doenças geneticamente associadas a AARS2 ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ «Entrez Gene: alanyl-tRNA synthetase 2»
↑ Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (março de 2005). «Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS». Biochemistry. 44 (12): 4805–16. PMID 15779907. doi:10.1021/bi047527z

Leitura adicional

Nakayama M, Kikuno R, Ohara O (novembro de 2002). «Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs». Genome Research. 12 (11): 1773–84. PMC 187542 . PMID 12421765. doi:10.1101/gr.406902
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (outubro de 1999). «Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Research. 6 (5): 337–45. PMID 10574462. doi:10.1093/dnares/6.5.337
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). «Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression». PLoS One. 5 (9): e12862. PMC 2943476 . PMID 20877624. doi:10.1371/journal.pone.0012862
Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (março de 2005). «Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS». Biochemistry. 44 (12): 4805–16. PMID 15779907. doi:10.1021/bi047527z
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (março de 2000). «Shotgun sequencing of the human transcriptome with ORF expressed sequence tags». Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. PMC 16267 . PMID 10737800. doi:10.1073/pnas.97.7.3491

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[1] «Doenças geneticamente associadas a AARS2 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[entrez-3] «Entrez Gene: alanyl-tRNA synthetase 2»

[pmid15779907-4] Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (março de 2005). «Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS». Biochemistry. 44 (12): 4805–16. PMID 15779907. doi:10.1021/bi047527z

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