ACAT2

ACAT2
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	1WL4, 1WL5
Identificadores
Nomes alternativos	ACAT2
IDs externos	OMIM: 100678 HomoloGene: 55855 GeneCards: ACAT2
Ontologia genética
Função molecular	• transferase activity; • acyltransferase activity; • catalytic activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • acyltransferase activity, transferring groups other than amino-acyl groups; • acetyl-CoA C-acetyltransferase activity; • acetyl-CoA C-acyltransferase activity;
Componente celular	• citoplasma; • nucléolo; • Exossoma; • núcleo celular; • mitocôndria; • citosol;
Processo biológico	• metabolismo; • metabolismo dos lipídios; • fatty acid beta-oxidation; • cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Ortólogos
	39
	n/a
	ENSG00000120437
	n/a
	Q9BWD1
	n/a
	NM_005891; NM_001303253
	n/a
	NP_001290182; NP_005882
	n/a
	Wikidata
Ver/Editar Humano

Acetil-CoA acetiltransferase, citosólica, também conhecida como acetoacetil-CoA tiolase citosólica, é uma enzima que em humanos é codificada pelo gene ACAT2 (acetil-Coenzima A acetiltransferase 2).^[2]

Referências

Leitura adicional editar

Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG (janeiro de 2008). «Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)». The Prostate. 68 (1): 20–33. PMID 18000807. doi:10.1002/pros.20674
Reynolds CA, Hong MG, Eriksson UK, Blennow K, Wiklund F, Johansson B, Malmberg B, Berg S, Alexeyenko A, Grönberg H, Gatz M, Pedersen NL, Prince JA (maio de 2010). «Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk». Human Molecular Genetics. 19 (10): 2068–78. PMC 2860895 . PMID 20167577. doi:10.1093/hmg/ddq079
He X, Lu Y, Saha N, Yang H, Heng CK (dezembro de 2005). «Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks». Human Genetics. 118 (3-4): 393–403. PMID 16195894. doi:10.1007/s00439-005-0055-3
Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, Yokoi K, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y (novembro de 2007). «Prediction of genetic risk for dyslipidemia». Genomics. 90 (5): 551–8. PMID 17919884. doi:10.1016/j.ygeno.2007.08.001
Kursula P, Sikkilä H, Fukao T, Kondo N, Wierenga RK (março de 2005). «High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I». Journal of Molecular Biology. 347 (1): 189–201. PMID 15733928. doi:10.1016/j.jmb.2005.01.018
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM (dezembro de 2008). «Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations». Journal of Lipid Research. 49 (12): 2582–9. PMID 18660489. doi:10.1194/jlr.M800232-JLR200
Parini P, Jiang ZY, Einarsson C, Eggertsen G, Zhang SD, Rudel LL, Han TQ, Eriksson M (novembro de 2009). «ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients». Atherosclerosis. 207 (1): 266–71. PMC 2784173 . PMID 19467657. doi:10.1016/j.atherosclerosis.2009.04.010
Pramfalk C, Angelin B, Eriksson M, Parini P (dezembro de 2007). «Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells». Biochemical and Biophysical Research Communications. 364 (2): 402–9. PMID 17950700. doi:10.1016/j.bbrc.2007.10.028
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (setembro de 2004). «Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions». Genome Research. 14 (9): 1711–8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y (maio de 2009). «Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension». Hypertension Research. 32 (5): 411–8. PMID 19282863. doi:10.1038/hr.2009.22
Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S (fevereiro de 2008). «Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma». International Journal of Urology. 15 (2): 166–70. PMID 18269457. doi:10.1111/j.1442-2042.2007.01947.x
Yao XM, Wang CH, Song BL, Yang XY, Wang ZZ, Qi W, Lin ZX, Chang CC, Chang TY, Li BL (dezembro de 2005). «Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes». Acta Biochimica et Biophysica Sinica. 37 (12): 797–806. PMID 16331323. doi:10.1111/j.1745-7270.2005.00118.x
Ohta T, Takata K, Katsuren K, Fukuyama S (junho de 2004). «The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects». Biochimica et Biophysica Acta. 1682 (1-3): 56–62. PMID 15158756. doi:10.1016/j.bbalip.2004.01.008
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S (fevereiro de 2009). «Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone». Clinica Chimica Acta; International Journal of Clinical Chemistry. 400 (1-2): 48–55. PMID 18996102. doi:10.1016/j.cca.2008.10.009
Jiang ZY, Jiang CY, Wang L, Wang JC, Zhang SD, Einarsson C, Eriksson M, Han TQ, Parini P, Eggertsen G (janeiro de 2009). «Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients». Biochemical and Biophysical Research Communications. 379 (1): 49–54. PMID 19071091. doi:10.1016/j.bbrc.2008.11.131
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Molecular Systems Biology. 3 (1). 89 páginas. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134

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[1] «Human PubMed Reference:»

[entrez-2] «Entrez Gene: acetyl-Coenzyme A acetyltransferase 2»

[2]

[1]