CCNC

CCNC
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBE, 5HBH, 5BNJ, 5HBJ, 5FGK, 5CEI, 5HNB, 5HVY, 5I5Z
Identificadores
Nomes alternativos	CCNC, ciclina-C
IDs externos	OMIM: 123838 HomoloGene: 3803 GeneCards: CCNC
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein serine/threonine kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity;
Componente celular	• mediator complex; • cyclin-dependent protein kinase holoenzyme complex; • núcleo celular; • cariolinfa;
Processo biológico	• positive regulation of phosphorylation of RNA polymerase II C-terminal domain; • transcription initiation from RNA polymerase II promoter; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • protein phosphorylation; • transcription, DNA-templated; • regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	892
	n/a
	ENSG00000112237
	n/a
	P24863
	n/a
	NM_001013399; NM_005190; NM_001363537
	n/a
	NP_001013417; NP_005181; NP_001350466
	n/a
	Wikidata
Ver/Editar Humano

A ciclina-C é uma proteína que em humanos é codificada pelo gene CCNC. A proteína codificada por este gene é um membro da família de proteínas ciclina.^[2]^[3] A proteína codificada interage com quinase 8 dependente de ciclina e induz a fosforilação do domínio carboxi-terminal da subunidade grande da RNA polimerase II.^[3]

Referências

↑ «Human PubMed Reference:»
↑ Lew DJ, Dulic V, Reed SI (outubro de 1991). «Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast». Cell. 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W
↑ ^a ^b «Entrez Gene: CCNC cyclin C»

Leitura adicional editar

Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). «Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)». Bioinorganic Chemistry. 5 (3): 267–73. PMID 1260071. doi:10.1016/S0006-3061(00)82025-6
Tassan JP, Jaquenoud M, Léopold P, et al. (1995). «Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C». Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. PMC 41069 . PMID 7568034. doi:10.1073/pnas.92.19.8871
Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). «Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)». Cytogenet. Cell Genet. 69 (3–4): 190–2. PMID 7698009. doi:10.1159/000133960
Yoshizumi M, Lee WS, Hsieh CM, et al. (1995). «Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts». J. Clin. Invest. 95 (5): 2275–80. PMC 295840 . PMID 7738192. doi:10.1172/JCI117918
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Rickert P, Seghezzi W, Shanahan F, et al. (1996). «Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II». Oncogene. 12 (12): 2631–40. PMID 8700522
Li H, Lahti JM, Valentine M, et al. (1997). «Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors». Genomics. 32 (2): 253–9. PMID 8833152. doi:10.1006/geno.1996.0112
Cujec TP, Cho H, Maldonado E, et al. (1997). «The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme». Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028 . PMID 9121429. doi:10.1128/MCB.17.4.1817
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Neish AS, Anderson SF, Schlegel BP, et al. (1998). «Factors associated with the mammalian RNA polymerase II holoenzyme». Nucleic Acids Res. 26 (3): 847–53. PMC 147327 . PMID 9443979. doi:10.1093/nar/26.3.847
Cho H, Orphanides G, Sun X, et al. (1998). «A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure». Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120 . PMID 9710619. doi:10.1128/MCB.18.9.5355
Sun X, Zhang Y, Cho H, et al. (1998). «NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription». Mol. Cell. 2 (2): 213–22. PMID 9734358. doi:10.1016/S1097-2765(00)80131-8
Gu W, Malik S, Ito M, et al. (1999). «A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation». Mol. Cell. 3 (1): 97–108. PMID 10024883. doi:10.1016/S1097-2765(00)80178-1
Ito M, Yuan CX, Malik S, et al. (1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell. 3 (3): 361–70. PMID 10198638. doi:10.1016/S1097-2765(00)80463-3
Rachez C, Lemon BD, Suldan Z, et al. (1999). «Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex». Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. PMID 10235266. doi:10.1038/19783
Wang G, Cantin GT, Stevens JL, Berk AJ (2001). «Characterization of Mediator Complexes from HeLa Cell Nuclear Extract». Mol. Cell. Biol. 21 (14): 4604–13. PMC 87123 . PMID 11416138. doi:10.1128/MCB.21.14.4604-4613.2001
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). «Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3». J. Biol. Chem. 278 (17): 15123–7. PMID 12584197. doi:10.1074/jbc.C300054200
Ueberham U, Hessel A, Arendt T (2003). «Cyclin C expression is involved in the pathogenesis of Alzheimer's disease». Neurobiol. Aging. 24 (3): 427–35. PMID 12600719. doi:10.1016/S0197-4580(02)00132-X

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[1] «Human PubMed Reference:»

[pmid1833066-2] Lew DJ, Dulic V, Reed SI (outubro de 1991). «Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast». Cell. 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W

[entrez-3] «Entrez Gene: CCNC cyclin C»

[2]

[3]

[1]