CPLX2
gene da espécie Homo sapiens
A complexina 2 (também conhecida como CPLX2), é uma proteína que em seres humanos é codificada pelo gene CPLX2.[1]
As proteínas codificadas pela família genética complexina/sinapsina são proteínas citosólicas que actuam na exocitose de vesículas sinápticas. Estas proteínas ligam-se à sintaxina, parte do receptor SNAP. O produto proteíco deste gene liga-se ao receptor SNAP, causando a sua disrupção e assim causando a libertação de transmissor. Duas variantes de transcriptos codificando a mesma proteína foram encontradas para este gene.[1]
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- Eastwood SL, Harrison PJ (2001). «Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins.». Brain Res. Bull. 55 (5): 569–78. PMID 11576753. doi:10.1016/S0361-9230(01)00530-5
- Pabst S, Margittai M; Vainius D,; et al. (2002). «Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.». J. Biol. Chem. 277 (10): 7838–48. PMID 11751907. doi:10.1074/jbc.M109507200
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- Strausberg RL, Feingold EA; Grouse LH,; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899 - Edwardson JM, Wang CT; Gong B,; et al. (2003). «Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.». J. Biol. Chem. 278 (33): 30849–53. PMID 12807877. doi:10.1074/jbc.M304615200
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- DiProspero NA, Chen EY; Charles V,; et al. (2005). «Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements.». J. Neurocytol. 33 (5): 517–33. PMID 15906159. doi:10.1007/s11068-004-0514-8
