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Catecol O-Metiltransferase

A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas (dopamina, epinefrina e norepinefrina).[3]

COMT
Catechol-O-methyl transferase 3bwm.png
Estruturas disponíveis
PDBPesquisa Human UniProt: PDBe RCSB
Identificadores
Nomes alternativosCOMT
IDs externosOMIM: 116790 HomoloGene: 30982 GeneCards: COMT
Targeted by Drug
entacapone, tolcapona[1]
Wikidata
Ver/Editar Humano

Referências

  1. «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata» 
  2. «Human PubMed Reference:» 
  3. «Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em November 16, 2016. Cópia arquivada em September 18, 2008  Parâmetro desconhecido |url-status= ignorado (ajuda); Verifique data em: |acessodata=, |arquivodata= (ajuda)
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Leitura adicionalEditar

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  • Zhu BT (October 2002). «On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis». Histology and Histopathology. 17 (4): 1283–91. PMID 12371153  Verifique data em: |data= (ajuda)
  • Oroszi G, Goldman D (December 2004). «Alcoholism: genes and mechanisms». Pharmacogenomics. 5 (8): 1037–48. PMID 15584875. doi:10.1517/14622416.5.8.1037  Verifique data em: |data= (ajuda)
  • Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (January 2005). «Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis». Biological Psychiatry. 57 (2): 139–44. PMID 15652872. doi:10.1016/j.biopsych.2004.10.018  Verifique data em: |data= (ajuda)
  • Tunbridge EM, Harrison PJ, Weinberger DR (July 2006). «Catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond». Biological Psychiatry. 60 (2): 141–51. PMID 16476412. doi:10.1016/j.biopsych.2005.10.024  Verifique data em: |data= (ajuda)
  • Craddock N, Owen MJ, O'Donovan MC (May 2006). «The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons». Molecular Psychiatry. 11 (5): 446–58. PMID 16505837. doi:10.1038/sj.mp.4001808  Verifique data em: |data= (ajuda)
  • Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (October 2007). «Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning». Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16311–6. PMC 2042203 . PMID 17913879. doi:10.1073/pnas.0706111104  Verifique data em: |data= (ajuda)
  • Greenberg, Gary (November 7, 2018). «What If the Placebo Effect Isn't a Trick?». New York Times Magazine  Verifique data em: |data= (ajuda)