Norflurazepam

Norflurazepam Alerta sobre risco à saúde


Nome IUPAC	7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Outros nomes	N-desalquilflurazepam
Identificadores
Número CAS	2886-65-9
PubChem	4540
ChemSpider	4381
SMILES	`Fc1ccccc1C2=NCC(=O)Nc3ccc(Cl)cc23`
Propriedades
Fórmula química	C₁₅H₁₀ClFN₂O
Massa molar	288.7 g mol^-1
Ponto de fusão	205
Farmacologia
Página de dados suplementares
Estrutura e propriedades	n, ε_r, etc.
Dados termodinâmicos	Phase behaviour Solid, liquid, gas
Dados espectrais	UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a materiais sob condições normais de temperatura e pressão Referências e avisos gerais sobre esta caixa. Alerta sobre risco à saúde.

Norflurazepam (também conhecido como N-desalquilflurazepam) é um análogo da benzodiazepina e um metabólito ativo de vários outros medicamentos benzodiazepínicos, incluindo flurazepam,^[1] flutoprazepam,^[2] fludiazepam,^[3] midazolam,^[4] flutazolam^[5], quazepam,^[6] e loflazepato de etilo.^[7]^[8] Tem ação prolongada, com tendência a se acumular no organismo e se liga de forma não seletiva a vários subtipos de receptores de benzodiazepina. Foi vendido como droga sintética de 2016 em diante.^[9]

Sinônimos editar

N-1-Desalquilflurazepam
N-desalquil-2-oxoquazepam
N-desalquilflutoprazepam
Ro 5-3367
TL8002277

Ver também editar

Lista de benzodiazepinas

Referências

↑ Riva R, de Anna M, Albani F, Baruzzi A. «Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas-liquid chromatography with electron-capture detection». Journal of Chromatography. 222: 491–5. PMID 7228960. doi:10.1016/S0378-4347(00)84153-5
↑ Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E (1989). «Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects». European Journal of Drug Metabolism and Pharmacokinetics. 14: 293–8. PMID 2633923. doi:10.1007/bf03190114
↑ Human Toxicology. Elsevier Science 1st ed. [S.l.: s.n.] 1996
↑ Vogt S, Kempf J, Buttler J, Auwärter V, Weinmann W (2013). «Desalkylflurazepam found in patients' samples after high-dose midazolam treatment». Drug Testing and Analysis. 5: 745–7. PMID 23713025. doi:10.1002/dta.1484
↑ Miyaguchi H, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT, Inoue H, Kishi T. «A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry». Forensic Science International. 157: 57–70. PMID 15869852. doi:10.1016/j.forsciint.2005.03.011
↑ Nikaido AM, Ellinwood EH (1987). «Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance». Psychopharmacology. 92: 459–64. PMID 2888152. doi:10.1007/bf00176478
↑ Ba BB, Iliadis A, Cano JP. «Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites». Annals of Biomedical Engineering. 17: 633–46. PMID 2574017. doi:10.1007/bf02367467
↑ Davi H, Guyonnet J, Necciari J, Cautreels W. «Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: comparison with solvent extraction and thin-layer chromatography». Journal of Chromatography. 342: 159–65. PMID 2864352. doi:10.1016/S0378-4347(00)84498-9
↑ Manchester KR, Maskell PD, Waters L. «a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances». Drug Testing and Analysis. 10: 1258–1269. PMID 29582576. doi:10.1002/dta.2387

Este artigo sobre fármacos é um esboço. Você pode ajudar a Wikipédia expandindo-o.

[:0-1] Riva R, de Anna M, Albani F, Baruzzi A. «Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas-liquid chromatography with electron-capture detection». Journal of Chromatography. 222: 491–5. PMID 7228960. doi:10.1016/S0378-4347(00)84153-5

[2] Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E (1989). «Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects». European Journal of Drug Metabolism and Pharmacokinetics. 14: 293–8. PMID 2633923. doi:10.1007/bf03190114

[3] Human Toxicology. Elsevier Science 1st ed. [S.l.: s.n.] 1996

[4] Vogt S, Kempf J, Buttler J, Auwärter V, Weinmann W (2013). «Desalkylflurazepam found in patients' samples after high-dose midazolam treatment». Drug Testing and Analysis. 5: 745–7. PMID 23713025. doi:10.1002/dta.1484

[5] Miyaguchi H, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT, Inoue H, Kishi T. «A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry». Forensic Science International. 157: 57–70. PMID 15869852. doi:10.1016/j.forsciint.2005.03.011

[Nikaido-6] Nikaido AM, Ellinwood EH (1987). «Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance». Psychopharmacology. 92: 459–64. PMID 2888152. doi:10.1007/bf00176478

[7] Ba BB, Iliadis A, Cano JP. «Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites». Annals of Biomedical Engineering. 17: 633–46. PMID 2574017. doi:10.1007/bf02367467

[8] Davi H, Guyonnet J, Necciari J, Cautreels W. «Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: comparison with solvent extraction and thin-layer chromatography». Journal of Chromatography. 342: 159–65. PMID 2864352. doi:10.1016/S0378-4347(00)84498-9

[9] Manchester KR, Maskell PD, Waters L. «a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances». Drug Testing and Analysis. 10: 1258–1269. PMID 29582576. doi:10.1002/dta.2387

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]