COX-3
COX-3 é uma recente descoberta de isoforma de ciclo-oxigenase, encontrada no cérebro, medula espinhal e coração. A estrutura química corresponde a da COX-1, exceto pelo íntron 1.[1]
Foi sugerida por Daniel L. Simmons e sua equipe e acredita-se que este tipo esteja presente no sistema nervoso central devido os efeitos do paracetamol (provável inibidor mais seletivo desta forma) e não tanto de COX-2 e COX-1 na periferia.[2]
Modula a dor e febre no SNC
Notas e referências
- ↑ Guía farmacológica de analgésicos
- ↑ SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006
Leitura adicional
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